PIOGLITAZONE

Pioglitazone

5-[[4-[2-(5-ethyl-2-pyridinyl)-ethoxy]phenyl] methyl]- 2,4- thiazolidinedione

111025-46-8

 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Additional Names: (±)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione

Manufacturers’ Codes: AD-4833

Molecular Formula: C19H20N2O3S

Molecular Weight: 356.44

Percent Composition: C 64.02%, H 5.66%, N 7.86%, O 13.47%, S 9.00%

Properties: Colorless needles from DMF + water, mp 183-184°.

Melting point: mp 183-184°

Therap-Cat: Antidiabetic.

Pioglitazone (Actos) is a prescription drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. Actos was the tenth-best selling drug in the U.S. in 2008, with sales exceeding $2.4 billion. While pioglitazone does decrease blood sugar levels, studies on the main cardiovascular outcomes has not yielded statistically significant results. Its cardiovascular safety profile compares favorably with rosiglitazone(Avandia), which was withdrawn after concerns about an increased risk of cardiac events. Pioglitazone has been found to be associated with bladder tumors and has been withdrawn in some countries.

Medical uses

Pioglitazone is used for the treatment of diabetes mellitus type 2 either alone or in combination with a sulfonylurea, metformin, orinsulin. There was, however, no statistically significant difference in the main outcomes studied.

Pioglitazone has also been used to treat non-alcoholic steatohepatitis (fatty liver), but this use is presently considered experimental.

(RS)-5-(4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl)thiazolidine-2,4-dione
CLINICAL DATA
TRADE NAMES	Actos
AHFS/DRUGS.COM	monograph
MEDLINEPLUS	a699016
LICENCE DATA	EMA:Link, US FDA:link
PREGNANCY CAT.	C
LEGAL STATUS	UK: POM US: ℞-only
ROUTES	oral
PHARMACOKINETIC DATA
PROTEIN BINDING	>99%
METABOLISM	liver (CYP2C8)
HALF-LIFE	3–7 hours
EXCRETION	in bile
IDENTIFIERS
CAS NUMBER	111025-46-8
ATC CODE	A10BG03
PUBCHEM	CID 4829
IUPHAR LIGAND	2694
DRUGBANK	DB01132
CHEMSPIDER	4663
UNII	X4OV71U42S
KEGG	D08378
CHEBI	CHEBI:8228
CHEMBL	CHEMBL595
CHEMICAL DATA
FORMULA	C19H20N2O3S
MOL. MASS	356.44 g/mol

Derivative Type: Hydrochloride

CAS Registry Number: 112529-15-4

Manufacturers’ Codes: U-72107A

Trademarks: Actos (Takeda)

Molecular Formula: C19H20N2O3S.HCl

Molecular Weight: 392.90

Percent Composition: C 58.08%, H 5.39%, N 7.13%, O 12.22%, S 8.16%, Cl 9.02%

Properties: Colorless prisms from ethanol, mp 193-194°. Sol in DMF; slightly sol in ethanol; very slightly sol in acetone, acetonitrile. Practically insol in water; insol in ether.

Melting point: mp 193-194°

nda 021073, actos, 15-7-99, tablet, takeda usa,

ACTOSView pdf

US PATENT NO	EXPIRY DATE	PATENT USE CODE
5965584	Jun 19, 2016	U-753
6150383	Jun 19, 2016	U-418
6150384	Jun 19, 2016	U-419
6166042	Jun 19, 2016	U-414
6166043	Jun 19, 2016	U-415
6172090	Jun 19, 2016	U-416
6211205	Jun 19, 2016	U-410
6271243	Jun 19, 2016	U-411
6303640	Aug 9, 2016	U-425
6329404	Jun 19, 2016	U-753

Synthesis

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http://www.google.com/patents/WO2004101560A1?cl=en

Many thiazolidinedione derivatives or “glitazones” are known to exhibit hypoglycemic activity and/or blood lipid lowering activity and have been proposed for use in treating, inter alia, diabetes. Some of the more well known and/or studied glitazones include pioglitazone, troglitazone, and rosiglitazone. Pioglitazone, chemically 5-[[4-[2-(5-ethyl-2-pyridinyl)-ethoxy]phenyl] methyl]- 2,4- thiazolidinedione of formula

(1)

is a commercially approved antidiabetic agent. Pharmaceutical compositions comprising pioglitazone, as the hydrochloride salt, are marketed under the brand name ACTOS® (Takeda Chemical Ind.) for treatment of type II diabetes.

Pioglitazone and its hydrochloride have been disclosed in EP 193256 and corresponding U.S. Patent No. 4,687,777. In these patents, the glitazone, such as pioglitazone, can be formed by cyclizing an alpha-bromo acid ester (2) with thiourea. The resulting imino-thiazolidinone (3) is then hydrolyzed to make the corresponding glitazone. For pioglitazone, the reaction can be represented as follows:

The starting alpha-bromo acid ester (2) is taught to be prepared by Meerwein arylation. This process comprises preparing the corresponding aniline (4), diazotation thereof in the presence of hydrobromic acid, and coupling of the product of diazotation with an acrylic acid ester (5) under catalysis by cuprous oxide as shown below:

reduction

(4) (5)

However, forming the alpha-bromo acid ester by the Meerwein arylation reaction can be problematic. The sequence of reactions within this transformation must be controlled precisely. Otherwise the diazo-compound generated during the reaction would react with another nucleophile such as the bromide anion leading to a complicated outcome. Therefore, the reaction often gives a complicated result and lower chemical yield. Furthermore, the preparation of the starting aniline derivative (4) comprises a hydrogenation step that requires a special apparatus, which gives some difficulties when scaling-up.

EP 0 008 203, which is related to U.S. Patent Nos. 4,287,200 and 4,481,141, discloses additional glitazones, i.e., not pioglitazone, that can be formed by several possible methods. In addition to the general scheme described in EP 193256, two more synthetic routes are proposed. One technique comprises a cyclization reaction as shown below to form the intended glitazone:

However, the formation of the starting thiocyano compound is not described. The other technique mentioned in EP 0 008 203 involves coupling the thiazolidine-containing moiety and the substituted alkyl moiety via alkylation of a phenolic oxygen to form the glitazone. If applied to pioglitazone, the reaction would be represented as follows:

(9) (10)

Example 11

Pioglitazone (from 2-thiocyanato-3- {4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]- phenyl} -propionic acid). 0.50 g of 2-thiocyanato-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}- propionic acid was dissolved in 10 mL of methanesulfonic acid, and the resulting brown solution was stirred overnight. Then, the reaction mixture was poured onto crushed ice upon stirring and sodium hydrogencarbonate was added in portions to neutralize the mixture. Precipitated light brown crystals were filtered off and dried to give 0.70 g of raw product, which was further purified by mixing with 12 % ethanolic solution of hydrogen chloride. The undissolved portion was filtered off, and the filtrate was precipitated with sodium bicarbonate, which gave crystals of pioglitazone

with a m.ρ. of 180 – 184°C.

………………………………..

EP 0193256; ES 8705886; JP 1986267580; US 4687777

The condensation of 2-(5-ethyl-2-pyridyl)ethanol (I) with 4-fluoronitrobenzene (II) by means of NaH in DMF gives 4-[2-(5-ethyl-2-pyridyl)ethoxy]nitrobenzene (III), which is reduced with H2 over Pd/C in methanol to yield the corresponding aniline (IV). The reaction of (IV) with NaNO2/HBr and methyl acrylate (V) in acetone/methanol affords the 2-bromopropionate derivative (VI), which is cyclized with thiourea (VII) by means of NaOAc in refluxing ethanol to provide the 2-imino-4-thiazolidinone (VIII). Finally, this compound is hydrolyzed with refluxing 2N HCl.

http://www.drugfuture.com/synth/syndata.aspx?ID=164965

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EP 0506273

This compound has been obtained by several different methods. The reaction of 2-(5-ethyl-2-pyridyl)ethanol (I) with Ts-Cl and NaOH in THF gives the corresponding tosylate (II), which is condensed with 4-hydroxybenzaldehyde (IV) by means of BnNBu3Cl and NaOH or K2CO3 to yield the aryl ether (V) (1-3). The condensation of (V) with thiazolidine-2,4-dione (VI) in refluxing ethanol affords the 5-benzylidenethiazolidinedione (VII), which is finally reduced with H2 over Pd/C in DMF or dioxane. The reaction of 2-(5-ethyl-2-pyridyl)ethanol (I) with Ms-Cl and TEA in dichloromethane THF gives the corresponding mesylate (III), which is condensed with 4-hydroxybenzaldehyde (IV) by means of K2CO3 to yield the already reported aryl ether (V). The condensation of 2-(5-ethyl-2-pyridyl)ethanol (I) with 4-fluorobenzonitrile (VIII) by means of NaH gives 4-[2-(5-ethyl-2-pyridyl)ethoxy]benzonitrile (IX), which is reduced with RaNi and HCOOH to yield the already reported 4-ethoxybenzaldehyde derivative (V).

http://www.drugfuture.com/synth/syndata.aspx?ID=164965

………………………….

11th Symp Med Chem (Dec 4-5, Tokushima) 1990,Abst P-11

Two new related syntheses of pioglitazone hydrochloride have been described: 1) The condensation of 2-(5-ethylpyridin-2-yl)ethanol (I) with 4-hydroxybenzaldehyde (II) by means of benzyltributylammonium chloride, NaOH and tosyl chloride gives 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde (III), which is condensed with thiazolidine-2,4-dione (IV) in basic medium to afford 5-[-4-[2-(5-ethylpyridin-2-yl)ethoxy]benzylidene]thiazolidine-2,4-dione (V). Finally, this compound is hydrogenated in the usual way. 2) The condensation of alcohol (I) with 4-fluorobenzonitrile (VI) by means of NaH gives 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzonitrile (VII), which is reduced with Raney Nickel and formic acid to the aldehyde (III), already obtained.

http://www.drugfuture.com/synth/syndata.aspx?ID=164965

…………………..

http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-9-265

Beilstein J. Org. Chem. 2013, 9, 2265–2319.

Pioglitazone is clearly related to rosiglitazone (1.40) with its structure only differing in the substitution pattern of the parent pyridine ring. Its synthesis begins with the hydroxymethylation of 2-methyl-5-ethylpyridine (1.11), a commodity chemical obtained from the condensation of acetaldehyde with ammonium acetate (Scheme 12) [43].

At elevated temperatures and pressures 2-methyl-5-ethylpyridine undergoes a condensation reaction with formaldehyde allowing isolation of the chain extended hydroxyethylpyridine 1.70upon distillation although in poor yield [44].

Following subsequent SNAr reaction aryl ether 1.71 is obtained, which is used as crude material in the subsequent Knoevenagel condensation with thiazolidinedione 1.68. In order to reduce the intermediate benzylidene double bond in this example sodium borohydride is used in the presence of cobalt chloride efficiently delivering pioglitazone in high purity.

Scheme 12: Synthesis of pioglitazone.

Other syntheses of pioglitazone use related pyridine building blocks and aim to generate late stage intermediates that deliver the target compound upon de novo synthesis of the thiazolidinedione ring system. For instance phenyl ether1.73 can be obtained via Williamson ether synthesis between mesylate 1.74and phenol 1.75 (Scheme 13).

Removal of the acetyl protecting group under acidic conditions renders aniline1.76 which is subsequently subjected to a Meerwein arylation reaction which occurs via diazotisation and subsequent treatment with acrylonitrile in the presence of cuprous oxide [45-48].

Scheme 13: Meerwein arylation reaction towards pioglitazone.

Alternatively, an equivalent acid functional material can be prepared starting from tyrosine (1.78) via a dual protection of the amino acid unit as the methyl ester and the amine as the benzaldehyde imine (Scheme 14). This is then followed by analogous ether formation with the previously generated mesylate1.74.

Intermediate 1.80 is then hydrolysed to reveal once again the amino acid functionality, which upon diazotisation in the presence of hydrobromic acid selectively forms the α-bromo ester 1.82.

Scheme 14: Route towards pioglitazone utilising tyrosine.

A more direct SNAr approach utilising 4-fluorobenzonitrile as the acceptor and the sodium alkoxide of hydroxyethylpyridine 1.84 as the nucleophile has been successfully conducted (Scheme 15) [49].

The nitrile unit is partially reduced and hydrolysed to the benzaldehyde 1.71using Raney-Ni under transfer hydrogenation conditions in wet formic acid. A Darzens reaction between this aldehyde and ethyl chloroacetate in the presence of sodium ethoxide delivers epoxide 1.87.

The material is next subjected to hydrogenolysis using Pd/C in methanol with a 1 bar hydrogen pressure to reductively ring open the epoxide. Finally, the transformation of the alcohol to the mesylate 1.88 occurs under standard conditions.

Scheme 15: Route towards pioglitazone via Darzens ester formation.

In order to complete the syntheses of pioglitazone as outlined in the previous schemes several procedures for the installation of the thiazolidinedione ring system have been reported [50]. For instance the α-bromoester of intermediate1.82 will render the desired heterocycle upon treatment with sodium isothiocyanate (Scheme 16, A).

Alternatively, the α-amino acid portion of 1.81 can be diazotised under standard conditions and will subsequently deliver the same product when treated with lithium isothiocyanate (Scheme 16, B).

Finally, α-bromonitrile 1.77 can be condensed with thiourea to give pioglitazone after aqueous work-up (Scheme 16, C).

Scheme 16: Syntheses of the thiazolidinedione moiety.

ref for above

43 Frank, R. L.; Pilgrim, F. J.; Riener, E. F. Org. Synth. 1950, 30.doi:10.1002/0471264180.os030.15

44 McGall, G. H.; Barone, A. D. Nucleic Acid Labeling Compounds. U.S. Patent 2001/0018514 A1, Aug 30, 2001.

45 Finch, H.; Fox, C.; Sajad, A. Respiratory Disease Treatment. W.O. Patent WO2010015818, Feb 11, 2010.

46 Adiyaman, M.; Guner, D.; Ridvanoglu, N.; Yurdakul, A. A. Process for the Production of substituted Phenyl Ethers. W.O. Patent WO2004000810, Dec 31, 2003.

47 Nersesian, D. L.; Black, L. A.; Miller, T. R.; Vortherms, T. A.; Esbenshade, T. A.; Hancock, A. A.; Cowart, M. D.Bioorg. Med. Chem. Lett.2008, 18, 355–359. doi:10.1016/j.bmcl.2007.10.067
48 Halama, A.; Hejtmankova, L.; Lustig, P.; Richter, J.; Srsnova, L.; Jirman, J. Method for obtaining Pioglitazone as an antidiabetic agent. W.O. Patent WO02088120, Nov 7, 2002.

49 Thijs, L.; Zhu, J. Processes for making Pioglitazone and compounds of the processes. W.O. Patent WO2005080387, Sept 1, 2005.

50  Bhanja, C.; Jena, S. J. Chem. Pharm. Res. 2012, 4, 4323–4333.

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http://www.google.com/patents/WO2012153312A1?cl=en

Pioglitazone of Formula I, chemically (±)-5-[[4-[2-(5-ethyl-2- pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, is used as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes (non-insulin- dependent diabetes mellitus or “NIDDM”).

The commercially available form of pioglitazone is its monohydrochloride salt.

Dehydropioglitazone (hereinafter referred to as “DHP” or “DHP of Formula II”) is known as an intermediate in the synthesis of pioglitazone or salts thereof.

In addition, DHP is also present as a process impurity or degradation product in pioglitazone or salts thereof. Several reasons are attributed for the generation of DHP in pioglitazone. Some factors linked to the generation of this impurity include the incomplete reduction of DHP and the oxidation of pioglitazone during isolation or while on stability.

Several processes are known in the literature for making pioglitazone or a salt thereof, for example, U.S. Patent Nos. 4,687,777; 5,585,495; 4,812,570; 5,554,758; 5,952,509; and 6,100,403; U.S. Publications 2002/0106762 and 2002/0050563; WO 03/53367; WO 03/80056; WO 2004/07490; WO 2004/024059; WO 2004/101560; WO 2004/101561 , WO 2005/049610; WO 2008/075380; WO 2006/1 17654; WO

2008/142706; WO 2005/058827; WO 2009/104200; and WO 2009/133576.

U.S. Publication 2006/0252803 provides a process for the preparation of pioglitazone which involves dissolving DHP of Formula II in formic acid and hydrogenating with hydrogen in the presence of 10% Palladium on Carbon under 2 atmospheric pressures and a temperature of 80°C. This process reportedly provides pioglitazone having less than about 0.14 % of the impurity at RRT 0.64 (HPLC).

It also provides a process for the preparation of pioglitazone which involves combining DHP of Formula II with dimethylformamide and hydrogenating with hydrogen in the presence of Palladium on Carbon under 3 atmospheric pressures and a temperature of 50°C. It is reported that -68.5% of DHP was converted to pioglitazone, containing about 3.5 % impurities (HPLC).

U.S. Publication 2009/118514 provides various purification methods for pioglitazone. It provides obtaining a solution of pioglitazone with a mixture of dimethylformamide (DMF) and 4% water, DMF and 5% methanol, DMF and 10% methanol, 1 ,4-dioxane or DMF and isopropyl alcohol at a temperature of about 90°C and precipitating pioglitazone from the solution by cooling to a temperature of about 25°C.

U.S. Publication 2007/0078170 provides a process for the preparation of pioglitazone which involves obtaining a clear solution of pioglitazone in

dimethylformamide at 85°C and adding methanol at a temperature of 60°C and further cooling to 10°C to precipitate pioglitazone.

Impurities in pioglitazone or its hydrochloride salt, or any active pharmaceutical ingredient (“API”), are undesirable and, in extreme cases, might even be harmful to a patient being treated with a dosage form containing the API. The purity of an API is critical for commercialization. The product of a chemical reaction is rarely just the target compound. Side products and by-products of the reaction and adjunct reagents used in the reaction will, in most cases, also be present in the product in varying amounts. Extra effort is often required to get pharmaceutically acceptable levels of purity of the target compound.

EXAMPLES

Example 1 : Purification of Pioglitazone

Dimethylformamide (10 mL) was heated to 80°C to 82°C and pioglitazone (2 g) was added to the hot solution and stirred at 80°C to get a clear solution. The solution was cooled to 75 °C and mixture of acetone (10 mL) and methanol (10 mL) was added to the solution in 30 to 45 minutes at 70°C to 75°C. After complete addition, the reaction mass was cooled to 30°C to 35°C slowly in about 2 hours and was filtered. The solid was washed with dimethylformamide/acetone/methanol mixture (6 mL).

DHP impurity content after purification: 0.05%

DHP impurity content before purification: 0.16%

Yield: 90% Example 2: Purification of Pioglitazone

Dimethylformamide (200 mL) was heated to 80°C to 85 °C and pioglitazone (40 g) was added to the hot solution and stirred at 80°C to get a clear solution. The solution was cooled to 75°C and mixture of acetone (200 mL) and methanol (200 mL) was added to this solution in 30 minutes to 45 minutes at 65°C to 75°C. After complete addition, the reaction mass was cooled to 30°C to 35°C slowly in about 2 hours and was filtered. The solid was washed with acetone/methanol mixture (100 mL).

DHP impurity content after purification: 0.04%

DHP impurity content before purification: 0.15%

Yield: 92%

Example 3: Purification of Pioglitazone (Control)

Dimethylformamide (25 mL) was heated to 80°C to 85 °C and pioglitazone (5 g) was added at 85°C. The solution was cooled to 55°C and a mixture of acetone (25 mL) and methanol (25 mL) was added to the solution in 30 minutes to 45 minutes at 55°C to 60°C. After complete addition, the reaction mass was cooled to 35°C to 37°C slowly in about 2 hours and was filtered. The solid was washed with acetone/methanol mixture (10+lOmL).

DHP impurity content after purification: 0.11%

DHP impurity content before purification: 0.12%

Yield: 92%

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http://www.google.com/patents/US20070078170

EXAMPLE 5

Conversion of Pioglitazone to Pioglitazone Hydrochloride

Pioglitazone hydrochloride was prepared in a similar manner as exemplified in Example 4. To de-ionized water (7 L) heated to 80° C. added the product obtained from Example 4 (1 Kg) under stirring at 80° C. It was further stirred for 10 min at 80 – 82° C. and conc. HCI (0.5 L) was added to it under stirring at 80° C. The resultant mass was further stirred for 10 min at 80-82° C. to obtain a clear solution. The solution was filtered through celite bed directly into RB flask and the bed was washed with IN HCI (1 L) at 80-82° C. It was cooled to 5° C. under stirring at 5-0° C. for 1 hr. The solids were filtered under N2atmosphere and dried on the Büchner funnel for about 15 minutes. The product obtained was then dried under vacuum at 55-60° C. to afford the title compound.

Yield: 930.0 g (93%)

HPLC Purity: 99.61%

Samples of pioglitazone hydrochloride prepared in examples 4 and 5 were studied for their solubility, as set forth below:

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Literature References:

Insulin sensitizer. Prepn: K. Meguro, T. Fujita, EP 193256; eidem, US 4687777(1986, 1987 both to Takeda);

T. Sohda et al., Arzneim.-Forsch. 40, 37 (1990).

Pharmacology: H. Ikeda et al., ibid. 156. HPLC determn in serum: W. Z. Zhong, D. B. Lakings, J. Chromatogr. 490, 377 (1989).

Mechanism of action: C. Hofmann et al., Endocrinology 129, 1915 (1991); M. Kobayashi et al., Diabetes 41, 476 (1992).

Effect on adipocyte differentiation: T. Sandouk et al., Am. J. Physiol. 264,C1600 (1993).

Clinical evaluation in noninsulin-dependent diabetes: R. Kawamori et al.,Diabetes Res. Clin. Pract. 41, 35 (1998).

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WO2012153312A1	May 11, 2012	Nov 15, 2012	Ranbaxy Laboratories Limited	Process for the purification of pioglitazone

WO2003053367A2	Dec 20, 2002	Jul 3, 2003	Ben-Zion Dolitzky	Hydrogenation of precursors to thiazolidinedione antihyperglycemics
WO2003080056A2	Mar 21, 2003	Oct 2, 2003	Ben-Zion Dolitzky	Fine particle size pioglitazone
WO2004007490A2	Jul 15, 2003	Jan 22, 2004	Cadila Healthcare Ltd	A process to prepare pioglitazone via several intermediates.
WO2004024059A2	Aug 29, 2003	Mar 25, 2004	Parag Narayan Gadkari	Improved process for preparation of thiazolidinedione derivatives
WO2004101560A1	May 11, 2004	Nov 25, 2004	Frantisek Picha	Processes for making thiazolidinedione derivatives and compounds thereof
WO2004101561A1	May 13, 2004	Nov 25, 2004	Frantisek Picha	Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same
WO2005049610A1	Oct 27, 2004	Jun 2, 2005	Sudhir Nambiar	Process for preparing thiazolidinediones
WO2005058827A1	Dec 16, 2004	Jun 30, 2005	Janos Fischer	Process for the synthesis of pioglitazone hydrogen chloride
WO2006117654A1	May 3, 2006	Nov 9, 2006	Ranbaxy Lab Ltd	Processes for the preparation of pioglitazone or salts thereof
WO2008075380A2	Dec 20, 2007	Jun 26, 2008	Ind Swift Lab Ltd	Process for the preparation of thiazolidine derivatives
WO2008142706A2	May 19, 2008	Nov 27, 2008	Yogendra Kumar Chauhan	Novel process for the synthesis of pioglitazone and its salts thereof
WO2009104200A1	Apr 8, 2008	Aug 27, 2009	Biocon Limited	A method for preparation of thiazolidinedione derivatives
WO2009133576A1	Apr 28, 2008	Nov 5, 2009	Erregierre S.P.A.	A process for the preparation of 4-[2-(5-ethyl-2-pyridyl)ethoxy]nitrobenzene and pioglitazone
US4687777	Jan 17, 1986	Aug 18, 1987	Takeda Chemical Industries, Ltd.	Thiazolidinedione derivatives, useful as antidiabetic agents
US4812570	Jul 14, 1987	Mar 14, 1989	Takeda Chemical Industries, Ltd.	Method for producing thiazolidinedione derivatives
US5554758	Jun 7, 1995	Sep 10, 1996	Takeda Chemical Industries, Ltd.	P-/2-/5-ethyl-2-pyridyl/ethoxy/benzaldehyde
US5585495	Dec 4, 1992	Dec 17, 1996	The Upjohn Company	Using a cobalt compound, ligand and reducing agent
US5952509	Jun 23, 1997	Sep 14, 1999	Takeda Chemical Industries, Ltd.	Reacting p-hydroxybenzaldehyde with a pyridyl-ethyl sulfonate derivative to form 4-(2-(substituted or nonsubstituted-2-pyridyl)ethoxy) benzaldehyde
US6100403	Apr 12, 1999	Aug 8, 2000	Takeda Chemical Industries, Ltd.	Production of benzaldehyde compounds
US20020050563	Sep 14, 2001	May 2, 2002	Smithkline Beecham P.L.C.	Process for the preparation of pharmaceutically active thiazolidine or oxazolidine compounds by a yeast reductase
US20020106762	Oct 9, 2001	Aug 8, 2002	Smith Kline Beecham Plc	Generating preerential compound for use as prophylactic agent; obtain chemical intermediate, incubate with enzyme, recover prophylactic agent
US20060252803	Jan 26, 2006	Nov 9, 2006	Ben-Zion Dolitzky	Hydrogenation of precursors to thiazolidinedione antihyperglycemics
US20070078170	Aug 30, 2004	Apr 5, 2007	Khanduri Chandra H	Process for the preparation of pioglitazone
US20090118514	Nov 5, 2008	May 7, 2009	Raghupathi Reddy Anumula	Processes for preparing pioglitazone and its pharmaceutically acceptable salts

WO2012153312A1	May 11, 2012	Nov 15, 2012	Ranbaxy Laboratories Limited	Process for the purification of pioglitazone
EP1734036A1 *	Jun 14, 2005	Dec 20, 2006	Well-being Biochemical Corp.	Process for preparation of tamsulosin and its derivatives

WO1997031907A1*	Feb 26, 1997	Sep 4, 1997	Grady Evan Boswell	Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to ppar-gamma
WO2002088120A1*	Apr 25, 2002	Jul 11, 2002	Ales Halama	Method for obtaining pioglitazone as an antidiabetic agent
EP0008203A1 *	Aug 3, 1979	Feb 20, 1980	Takeda Chemical Industries, Ltd.	Thiazolidine derivatives, preparing same and pharmaceutical compositions comprising same
EP0193256A1 *	Jan 15, 1986	Sep 3, 1986	Takeda Chemical Industries, Ltd.	Thiazolidinedione derivatives, their production and use

Keywords: Antidiabetic; Thiazolidinediones; Insulin Sensitizer.